![](/images/graphics-bg.png)
Thromboembolic Events Associated with Thalidomide and Multimodality Therapy for Soft Tissue Sarcomas: Results of RTOG 0330
Joint Authors
Lucas, D. R.
Curran, W. J.
Ettinger, D. S.
DeLaney, Thomas F.
Kane, J. M.
Harris, J.
Kraybill, W. G.
Wang, D.
Harmon, D. C.
Eisenberg, B. L.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
RTOG 0330 was developed to address the toxicity of RTOG 9514 and to add thalidomide (THAL) to MAID chemoradiation for intermediate/high grade soft tissue sarcomas (STSs) and to preoperative radiation (XRT) for low-grade STS.
Methods.
Primary/locally recurrent extremity/trunk STS: ≥8 cm, intermediate/high grade (cohort A): >5 cm, low grade (cohort B).
Cohort A: 3 cycles of neoadjuvant MAID, 2 cycles of interdigitated THAL (200 mg/day)/concurrent 22 Gy XRT, resection, 12 months of adjuvant THAL.
Cohort B: neoadjuvant THAL/concurrent 50 Gy XRT, resection, 6 months of adjuvant THAL.
Planned accrual 44 patients.
Results.
22 primary STS patients (cohort A/B 15/7).
Cohort A/B: median age of 49/47 years; median tumor size 12.8/10 cm.
100% preoperative THAL/XRT and surgical resection.
Three cycles of MAID were delivered in 93% cohort A.
Positive margins: 27% cohort A/29% cohort B.
Adjuvant THAL: 60% cohort A/57% cohort B.
Grade 3/4 venous thromboembolic (VTE) events: 40% cohort A (1 catheter thrombus and 5 DVT or PE) versus 0% cohort B.
RTOG 0330 closed early due to cohort A VTE risk and cohort B poor accrual.
Conclusion.
Neoadjuvant MAID with THAL/XRT was associated with increased VTE events not seen with THAL/XRT alone or in RTOG 9514 with neoadjuvant MAID/XRT.
American Psychological Association (APA)
Kraybill, W. G.& Harmon, D. C.& Ettinger, D. S.& Lucas, D. R.& DeLaney, Thomas F.& Wang, D.…[et al.]. 2012. Thromboembolic Events Associated with Thalidomide and Multimodality Therapy for Soft Tissue Sarcomas: Results of RTOG 0330. Complexity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002917
Modern Language Association (MLA)
Kraybill, W. G.…[et al.]. Thromboembolic Events Associated with Thalidomide and Multimodality Therapy for Soft Tissue Sarcomas: Results of RTOG 0330. Complexity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1002917
American Medical Association (AMA)
Kraybill, W. G.& Harmon, D. C.& Ettinger, D. S.& Lucas, D. R.& DeLaney, Thomas F.& Wang, D.…[et al.]. Thromboembolic Events Associated with Thalidomide and Multimodality Therapy for Soft Tissue Sarcomas: Results of RTOG 0330. Complexity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002917
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002917