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Notch, Wnt, and Hedgehog Pathways in Rhabdomyosarcoma: From Single Pathways to an Integrated Network
Joint Authors
Roma, Josep
Gallego, Soledad
Almazán-Moga, Anna
Sánchez de Toledo, Josep
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children.
Regarding histopathological criteria, RMS can be divided into 2 main subtypes: embryonal and alveolar.
These subtypes differ considerably in their clinical phenotype and molecular features.
Abnormal regulation or mutation of signalling pathways that regulate normal embryonic development such as Notch, Hedgehog, and Wnt is a recurrent feature in tumorigenesis.
Herein, the general features of each of the three pathways, their implication in cancer and particularly in RMS are reviewed.
Finally, the cross-talking among these three pathways and the possibility of better understanding of the horizontal communication among them, leading to the development of more potent therapeutic approaches, are discussed.
American Psychological Association (APA)
Roma, Josep& Almazán-Moga, Anna& Sánchez de Toledo, Josep& Gallego, Soledad. 2012. Notch, Wnt, and Hedgehog Pathways in Rhabdomyosarcoma: From Single Pathways to an Integrated Network. Complexity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002920
Modern Language Association (MLA)
Roma, Josep…[et al.]. Notch, Wnt, and Hedgehog Pathways in Rhabdomyosarcoma: From Single Pathways to an Integrated Network. Complexity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1002920
American Medical Association (AMA)
Roma, Josep& Almazán-Moga, Anna& Sánchez de Toledo, Josep& Gallego, Soledad. Notch, Wnt, and Hedgehog Pathways in Rhabdomyosarcoma: From Single Pathways to an Integrated Network. Complexity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002920