Genes Regulated in Metastatic Osteosarcoma: Evaluation by Microarray Analysis in Four Human and Two Mouse Cell Line Systems
Joint Authors
Muff, Roman
Ram Kumar, Ram Mohan
Fuchs, Bruno
Born, Walter
Botter, Sander M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Osteosarcoma (OS) is a rare bone neoplasm that affects mainly adolescents.
It is associated with poor prognosis in case of metastases formation.
The search for metastasis predicting markers is therefore imperative to optimize treatment strategies for patients at risk and important for the search of new drugs for the treatment of this devastating disease.
Here, we have analyzed by microarray the differential gene expression in four human and two mouse OS cell line systems consisting of parental cell lines with low metastatic potential and derivatives thereof with increased metastatic potential.
Using two osteoblastic cell line systems, the most common OS phenotype, we have identified forty-eight common genes that are differentially expressed in metastatic cell lines compared to parental cells.
The identified subset of metastasis relevant genes in osteoblastic OS overlapped only minimally with differentially expressed genes in the other four preosteoblast or nonosteoblastic cell line systems.
The results imply an OS phenotype specific expression pattern of metastasis regulating proteins and form a basis for further investigation of gene expression profiles in patients’ samples combined with survival analysis with the aim to optimize treatment strategies to develop new drugs and to consequently improve the survival of patients with the most common form of osteoblastic OS.
American Psychological Association (APA)
Muff, Roman& Ram Kumar, Ram Mohan& Botter, Sander M.& Born, Walter& Fuchs, Bruno. 2012. Genes Regulated in Metastatic Osteosarcoma: Evaluation by Microarray Analysis in Four Human and Two Mouse Cell Line Systems. Complexity،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1002937
Modern Language Association (MLA)
Muff, Roman…[et al.]. Genes Regulated in Metastatic Osteosarcoma: Evaluation by Microarray Analysis in Four Human and Two Mouse Cell Line Systems. Complexity No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1002937
American Medical Association (AMA)
Muff, Roman& Ram Kumar, Ram Mohan& Botter, Sander M.& Born, Walter& Fuchs, Bruno. Genes Regulated in Metastatic Osteosarcoma: Evaluation by Microarray Analysis in Four Human and Two Mouse Cell Line Systems. Complexity. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1002937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002937