Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry
Joint Authors
Levin, Michael
Pai, Vaibhav P.
Vandenberg, Laura N.
Blackiston, Douglas
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
16
Abstract EN
Consistent left-right asymmetry in organ morphogenesis is a fascinating aspect of bilaterian development.
Although embryonic patterning of asymmetric viscera, heart, and brain is beginning to be understood, less is known about possible subtle asymmetries present in anatomically identical paired structures.
We investigated two important developmental events: physiological controls of eye development and specification of neural crest derivatives, in Xenopus laevis embryos.
We found that the striking hyperpolarization of transmembrane potential (Vmem) demarcating eye induction usually occurs in the right eye field first.
This asymmetry is randomized by perturbing visceral left-right patterning, suggesting that eye asymmetry is linked to mechanisms establishing primary laterality.
Bilateral misexpression of a depolarizing channel mRNA affects primarily the right eye, revealing an additional functional asymmetry in the control of eye patterning by Vmem.
The ATP-sensitive K+ channel subunit transcript, SUR1, is asymmetrically expressed in the eye primordia, thus being a good candidate for the observed physiological asymmetries.
Such subtle asymmetries are not only seen in the eye: consistent asymmetry was also observed in the migration of differentiated melanocytes on the left and right sides.
These data suggest that even anatomically symmetrical structures may possess subtle but consistent laterality and interact with other developmental left-right patterning pathways.
American Psychological Association (APA)
Pai, Vaibhav P.& Vandenberg, Laura N.& Blackiston, Douglas& Levin, Michael. 2012. Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry. Stem Cells International،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-1002982
Modern Language Association (MLA)
Pai, Vaibhav P.…[et al.]. Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry. Stem Cells International No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-1002982
American Medical Association (AMA)
Pai, Vaibhav P.& Vandenberg, Laura N.& Blackiston, Douglas& Levin, Michael. Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-1002982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002982