Hematological- and Neurological-Expressed Sequence 1 Gene Products in Progenitor Cells during Newt Retinal Development
Joint Authors
Goto, Tatsushi
Tokunaga, Fumio
Hisatomi, Osamu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-06
Country of Publication
Egypt
No. of Pages
6
Abstract EN
Urodele amphibians such as Japanese common newts have a remarkable ability to regenerate their injured neural retina, even as adults.
We found that hematological- and neurological-expressed sequence 1 (Hn1) gene was induced in depigmented retinal pigment epithelial (RPE) cells, and its expression was maintained at later stages of newt retinal regeneration.
In this study, we investigated the distribution of the HN1 protein, the product of the Hn1 gene, in the developing retinas.
Our immunohistochemical analyses suggested that the HN1 protein was highly expressed in an immature retina, and the subcellular localization changed during this retinogenesis as observed in newt retinal regeneration.
We also found that the expression of Hn1 gene was not induced in mouse after retinal removal.
Our results showed that Hn1 gene can be useful for detection of undifferentiated and dedifferentiated cells during both newt retinal development and regeneration.
American Psychological Association (APA)
Goto, Tatsushi& Tokunaga, Fumio& Hisatomi, Osamu. 2012. Hematological- and Neurological-Expressed Sequence 1 Gene Products in Progenitor Cells during Newt Retinal Development. Stem Cells International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1003012
Modern Language Association (MLA)
Goto, Tatsushi…[et al.]. Hematological- and Neurological-Expressed Sequence 1 Gene Products in Progenitor Cells during Newt Retinal Development. Stem Cells International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1003012
American Medical Association (AMA)
Goto, Tatsushi& Tokunaga, Fumio& Hisatomi, Osamu. Hematological- and Neurological-Expressed Sequence 1 Gene Products in Progenitor Cells during Newt Retinal Development. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1003012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003012