Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish
Joint Authors
Rottbauer, Wolfgang
Keßler, Mirjam
Just, Steffen
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-13
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells.
Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels also feature ion flux independent functions during heart development and morphogenesis.
The zebrafish is a well-established animal model to decipher the genetics of cardiovascular development and disease of vertebrates.
In large scale forward genetics screens, hundreds of mutant lines have been isolated with defects in cardiovascular structure and function.
Detailed phenotyping of these lines and identification of the causative genetic defects revealed new insights into ion flux dependent and independent functions of various cardiac ion channels.
American Psychological Association (APA)
Keßler, Mirjam& Just, Steffen& Rottbauer, Wolfgang. 2012. Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish. Stem Cells International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1003022
Modern Language Association (MLA)
Keßler, Mirjam…[et al.]. Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish. Stem Cells International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1003022
American Medical Association (AMA)
Keßler, Mirjam& Just, Steffen& Rottbauer, Wolfgang. Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1003022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003022