Optimising Human Mesenchymal Stem Cell Numbers for Clinical Application: A Literature Review
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-31
Country of Publication
Egypt
No. of Pages
5
Abstract EN
Adult mesenchymal stem cells (MSCs) are being investigated further for their use in stem cell therapies.
However, as they are found in very low numbers in adult tissue, expansion in vitro is required to produce desired MSC numbers for clinical application.
The need for effective cell-based therapies is increasing due to a rise in the ageing population, increasing the prevalence of musculoskeletal disorders.
This review investigates how factors, age and gender of donor, as well as seeding density can affect MSC expansion.
Age and gender of donor have received mixed results from studies, whereas seeding density studies have produced consistent results for numerous MSC sources, favouring lower seeding densities.
Further research is required to reduce the risk of infection, loss of cell characterisation in cell culture, and making cell-based therapies more cost effective through creating rapid expansion of MSCs regardless of patient factors.
American Psychological Association (APA)
Fossett, E.& Khan, Wasim S.. 2012. Optimising Human Mesenchymal Stem Cell Numbers for Clinical Application: A Literature Review. Stem Cells International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1003024
Modern Language Association (MLA)
Fossett, E.& Khan, Wasim S.. Optimising Human Mesenchymal Stem Cell Numbers for Clinical Application: A Literature Review. Stem Cells International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-1003024
American Medical Association (AMA)
Fossett, E.& Khan, Wasim S.. Optimising Human Mesenchymal Stem Cell Numbers for Clinical Application: A Literature Review. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1003024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003024