Human Amniotic Fluid Cells Form Functional Gap Junctions with Cortical Cells
Joint Authors
Jezierski, Anna
Rennie, Kerry
Tremblay, Roger
Zurakowski, Bogdan
Gruslin, Andreé
Sikorska, Marianna
Bani-Yaghoub, Mahmud
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
16
Abstract EN
The usage of stem cells is a promising strategy for the repair of damaged tissue in the injured brain.
Recently, amniotic fluid (AF) cells have received a lot of attention as an alternative source of stem cells for cell-based therapies.
However, the success of this approach relies significantly on proper interactions between graft and host tissue.
In particular, the reestablishment of functional brain networks requires formation of gap junctions, as a key step to provide sufficient intercellular communication.
In this study, we show that AF cells express high levels of CX43 (GJA1) and are able to establish functional gap junctions with cortical cultures.
Furthermore, we report an induction of Cx43 expression in astrocytes following injury to the mouse motor cortex and demonstrate for the first time CX43 expression at the interface between implanted AF cells and host brain cells.
These findings suggest that CX43-mediated intercellular communication between AF cells and cortical astrocytes may contribute to the reconstruction of damaged tissue by mediating modulatory, homeostatic, and protective factors in the injured brain and hence warrants further investigation.
American Psychological Association (APA)
Jezierski, Anna& Rennie, Kerry& Tremblay, Roger& Zurakowski, Bogdan& Gruslin, Andreé& Sikorska, Marianna…[et al.]. 2012. Human Amniotic Fluid Cells Form Functional Gap Junctions with Cortical Cells. Stem Cells International،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-1003052
Modern Language Association (MLA)
Jezierski, Anna…[et al.]. Human Amniotic Fluid Cells Form Functional Gap Junctions with Cortical Cells. Stem Cells International No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-1003052
American Medical Association (AMA)
Jezierski, Anna& Rennie, Kerry& Tremblay, Roger& Zurakowski, Bogdan& Gruslin, Andreé& Sikorska, Marianna…[et al.]. Human Amniotic Fluid Cells Form Functional Gap Junctions with Cortical Cells. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-1003052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003052