Stem Cell Applications in Tendon Disorders: A Clinical Perspective

Author

Young, Mark

Source

Stem Cells International

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-01-29

Country of Publication

Egypt

No. of Pages

10

Abstract EN

Tendon injuries are a common cause of morbidity and a significant health burden on society.

Tendons are structural tissues connecting muscle to bone and are prone to tearing and tendinopathy, an overuse or degenerative condition that is characterized by failed healing and cellular depletion.

Current treatments, for tendon tear are conservative, surgical repair or surgical scaffold reconstruction.

Tendinopathy is treated by exercises, injection therapies, shock wave treatments or surgical tendon debridement.

However, tendons usually heal with fibrosis and scar tissue, which has suboptimal tensile strength and is prone to reinjury, resulting in lifestyle changes with activity restriction.

Preclinical studies show that cell therapies have the potential to regenerate rather than repair tendon tissue, a process termed tenogenesis.

A number of different cell lines, with varying degrees of differentiation, have being evaluated including stem cells, tendon derived cells and dermal fibroblasts.

Even though cellular therapies offer some potential in treating tendon disorders, there have been few published clinical trials to determine the ideal cell source, the number of cells to administer, or the optimal bioscaffold for clinical use.

American Psychological Association (APA)

Young, Mark. 2012. Stem Cell Applications in Tendon Disorders: A Clinical Perspective. Stem Cells International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1003067

Modern Language Association (MLA)

Young, Mark. Stem Cell Applications in Tendon Disorders: A Clinical Perspective. Stem Cells International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1003067

American Medical Association (AMA)

Young, Mark. Stem Cell Applications in Tendon Disorders: A Clinical Perspective. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1003067

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1003067