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Skin-Derived Precursor Cells as an In Vitro Modelling Tool for the Study of Type 1 Neurofibromatosis
Joint Authors
Gutiérrez-Rivera, Araika
Iribar, Haizea
Tuneu, Anna
Izeta, Ander
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
9
Abstract EN
The most characteristic feature of neurofibromatosis type 1 (NF1) is the development of neurofibromas.
It has been suggested that these tumors are caused by somatic inactivation of the wild-type NF1 allele, but the cell that originally suffers this mutation remains controversial.
Several lines of evidence support the clonal origin of these tumors, and it has been recently suggested that skin-derived precursor cells (SKPs) could be the cell of origin of dermal neurofibromas.
Nullizygous (NF1−/−) SKPs do give rise to neurofibromas when transplanted to heterozygous mice.
Moreover, a nullizygous population of cells that is S100β negative is present in human neurofibromas, and NF1+/− multipotent progenitor cells are seemingly recruited to the tumor.
This evidence supports the neurofibroma stem cell hypothesis and a putative involvement of SKPs in the aetiopathogenesis of the disease, suggesting that SKPs could become a valuable tool for the in vitro study of NF1.
American Psychological Association (APA)
Gutiérrez-Rivera, Araika& Iribar, Haizea& Tuneu, Anna& Izeta, Ander. 2012. Skin-Derived Precursor Cells as an In Vitro Modelling Tool for the Study of Type 1 Neurofibromatosis. Stem Cells International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1003071
Modern Language Association (MLA)
Gutiérrez-Rivera, Araika…[et al.]. Skin-Derived Precursor Cells as an In Vitro Modelling Tool for the Study of Type 1 Neurofibromatosis. Stem Cells International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1003071
American Medical Association (AMA)
Gutiérrez-Rivera, Araika& Iribar, Haizea& Tuneu, Anna& Izeta, Ander. Skin-Derived Precursor Cells as an In Vitro Modelling Tool for the Study of Type 1 Neurofibromatosis. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1003071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003071