In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue
Joint Authors
Ferris, Dora
Frisbie, David
Kisiday, John
McIlwraith, C. Wayne
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Fibrin glue created from a patient's own blood can be used as a carrier to deliver cells to the specific site of an injury.
An experimental model for optimizing various permutations of this delivery system in vivo was tested in this study.
Harvested equine meniscal sections were reapposed with fibrin glue or fibrin glue and equine bone marrow-derived mesenchymal stem cells (BMSCs).
These constructs were then implanted subcutaneously in nude mice.
After harvesting of the constructs, BMSC containing constructs showed significantly increased vascularization, and histology showed subjectively decreased thickness of repair tissue and increased total bonding compared to fibrin alone constructs.
This model allowed direct comparison of different meniscal treatment groups while using a small number of animals.
This in vivo model could be valuable in the future to optimize fibrin and cellular treatments for meniscal lesions in the horse and potentially humans as well.
American Psychological Association (APA)
Ferris, Dora& Frisbie, David& Kisiday, John& McIlwraith, C. Wayne. 2011. In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue. Stem Cells International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1003080
Modern Language Association (MLA)
Ferris, Dora…[et al.]. In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue. Stem Cells International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1003080
American Medical Association (AMA)
Ferris, Dora& Frisbie, David& Kisiday, John& McIlwraith, C. Wayne. In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue. Stem Cells International. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1003080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003080