In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue

Joint Authors

Ferris, Dora
Frisbie, David
Kisiday, John
McIlwraith, C. Wayne

Source

Stem Cells International

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-10-27

Country of Publication

Egypt

No. of Pages

9

Abstract EN

Fibrin glue created from a patient's own blood can be used as a carrier to deliver cells to the specific site of an injury.

An experimental model for optimizing various permutations of this delivery system in vivo was tested in this study.

Harvested equine meniscal sections were reapposed with fibrin glue or fibrin glue and equine bone marrow-derived mesenchymal stem cells (BMSCs).

These constructs were then implanted subcutaneously in nude mice.

After harvesting of the constructs, BMSC containing constructs showed significantly increased vascularization, and histology showed subjectively decreased thickness of repair tissue and increased total bonding compared to fibrin alone constructs.

This model allowed direct comparison of different meniscal treatment groups while using a small number of animals.

This in vivo model could be valuable in the future to optimize fibrin and cellular treatments for meniscal lesions in the horse and potentially humans as well.

American Psychological Association (APA)

Ferris, Dora& Frisbie, David& Kisiday, John& McIlwraith, C. Wayne. 2011. In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue. Stem Cells International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1003080

Modern Language Association (MLA)

Ferris, Dora…[et al.]. In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue. Stem Cells International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1003080

American Medical Association (AMA)

Ferris, Dora& Frisbie, David& Kisiday, John& McIlwraith, C. Wayne. In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue. Stem Cells International. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1003080

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1003080