Stem Cells as In Vitro Model of Parkinson's Disease
Joint Authors
Martínez-Morales, Patricia L.
Liste, Isabel
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Progress in understanding neurodegenerative cell biology in Parkinson's disease (PD) has been hampered by a lack of predictive and relevant cellular models.
In addition, the lack of an adequate in vitro human neuron cell-based model has been an obstacle for the uncover of new drugs for treating PD.
The ability to generate induced pluripotent stem cells (iPSCs) from PD patients and a refined capacity to differentiate these iPSCs into DA neurons, the relevant disease cell type, promises a new paradigm in drug development that positions human disease pathophysiology at the core of preclinical drug discovery.
Disease models derived from iPSC that manifest cellular disease phenotypes have been established for several monogenic diseases, but iPSC can likewise be used for phenotype-based drug screens in complex diseases for which the underlying genetic mechanism is unknown.
Here, we highlight recent advances as well as limitations in the use of iPSC technology for modelling PD “in a dish” and for testing compounds against human disease phenotypes in vitro.
We discuss how iPSCs are being exploited to illuminate disease pathophysiology, identify novel drug targets, and enhance the probability of clinical success of new drugs.
American Psychological Association (APA)
Martínez-Morales, Patricia L.& Liste, Isabel. 2012. Stem Cells as In Vitro Model of Parkinson's Disease. Stem Cells International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1003138
Modern Language Association (MLA)
Martínez-Morales, Patricia L.& Liste, Isabel. Stem Cells as In Vitro Model of Parkinson's Disease. Stem Cells International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1003138
American Medical Association (AMA)
Martínez-Morales, Patricia L.& Liste, Isabel. Stem Cells as In Vitro Model of Parkinson's Disease. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1003138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003138