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PHBVPCL Microparticles for Controlled Release of Resveratrol: Physicochemical Characterization, Antioxidant Potential, and Effect on Hemolysis of Human Erythrocytes
Joint Authors
Mendes, Jessica Bitencourt Emilio
Riekes, Manoela Klüppel
Mainardes, Rubiana Mara
Michel, Milton Domingos
Farago, Paulo Vitor
Zawadzki, Sônia Faria
de Oliveira, Viviane Matoso
Khalil, Najeh Maissar
Stulzer, Hellen Karine
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Microparticles of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(ε-caprolactone) (PCL) containing resveratrol were successfully prepared by simple emulsion/solvent evaporation.
All formulations showed suitable encapsulation efficiency values higher than 80%.
PHBV microparticles revealed spherical shape with rough surface and presence of pores.
PCL microparticles were spherically shaped with smooth surface.
Fourier-transformed infrared spectra demonstrated no chemical bond between resveratrol and polymers.
X-ray powder diffraction patterns and differential scanning calorimetry analyses indicated that microencapsulation led to drug amorphization.
These PHBV/PCL microparticles delayed the dissolution profile of resveratrol.
Release profiles were better fitted to biexponential equation.
The hypochlorous-acid-scavenging activity and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation discoloration assay confirmed that the antioxidant activity of PHBV/PCL microparticles was kept, but was dependent on the microparticle morphology and dissolution profile.
Resveratrol-loaded PHBV/PCL microparticles showed no cytotoxic effect on red blood cells.
American Psychological Association (APA)
Mendes, Jessica Bitencourt Emilio& Riekes, Manoela Klüppel& de Oliveira, Viviane Matoso& Michel, Milton Domingos& Stulzer, Hellen Karine& Khalil, Najeh Maissar…[et al.]. 2012. PHBVPCL Microparticles for Controlled Release of Resveratrol: Physicochemical Characterization, Antioxidant Potential, and Effect on Hemolysis of Human Erythrocytes. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1003163
Modern Language Association (MLA)
Mendes, Jessica Bitencourt Emilio…[et al.]. PHBVPCL Microparticles for Controlled Release of Resveratrol: Physicochemical Characterization, Antioxidant Potential, and Effect on Hemolysis of Human Erythrocytes. The Scientific World Journal No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1003163
American Medical Association (AMA)
Mendes, Jessica Bitencourt Emilio& Riekes, Manoela Klüppel& de Oliveira, Viviane Matoso& Michel, Milton Domingos& Stulzer, Hellen Karine& Khalil, Najeh Maissar…[et al.]. PHBVPCL Microparticles for Controlled Release of Resveratrol: Physicochemical Characterization, Antioxidant Potential, and Effect on Hemolysis of Human Erythrocytes. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1003163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003163