In Vivo Potential Anti-Inflammatory Activity of Melissa officinalis L. Essential Oil
Joint Authors
Cherrah, Yahia
Alnamer, Rachad
Zellou, Amina
Bounihi, Amina
Hajjaj, Ghizlane
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Melissa officinalis L.
(Lamiaceae) had been reported in traditional Moroccan medicine to exhibit calming, antispasmodic, and strengthening heart effects.
Therefore, this study is aimed at determining the anti-inflammatory activities of M.
officinalis L.
leaves.
The effect of the essential oil of the leaves of this plant was investigated for anti-inflammatory properties by using carrageenan and experimental trauma-induced hind paw edema in rats.
The essential oil extracted from leaves by hydrodistillation was characterized by means of gas chromatography-mass spectrometry (GC-MS).
M.
officinalis contained Nerol (30.44%), Citral (27.03%), Isopulegol (22.02%), Caryophyllene (2.29%), Caryophyllene oxide (1.24%), and Citronella (1.06%).
Anti-inflammatory properties of oral administration of essential oil at the doses of 200, 400 mg/kg p.o., respectively, showed significant reduction and inhibition of edema with 61.76% and 70.58%, respectively, (P<0.001) induced by carrageenan at 6 h when compared with control and standard drug (Indomethacin).
On experimental trauma, M.
officinalis L.
essential oil showed pronounced reduction and inhibition of edema induced by carrageenan at 6 h at 200 and 400 mg/kg with 91.66% and 94.44%, respectively (P<0.001).
We can conclude that the essential oil of M.
officinalis L.
possesses potential anti-inflammatory activities, supporting the traditional application of this plant in treating various diseases associated with inflammation and pain.
American Psychological Association (APA)
Bounihi, Amina& Hajjaj, Ghizlane& Alnamer, Rachad& Cherrah, Yahia& Zellou, Amina. 2013. In Vivo Potential Anti-Inflammatory Activity of Melissa officinalis L. Essential Oil. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003201
Modern Language Association (MLA)
Bounihi, Amina…[et al.]. In Vivo Potential Anti-Inflammatory Activity of Melissa officinalis L. Essential Oil. Advances in Pharmacological and Pharmaceutical Sciences No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1003201
American Medical Association (AMA)
Bounihi, Amina& Hajjaj, Ghizlane& Alnamer, Rachad& Cherrah, Yahia& Zellou, Amina. In Vivo Potential Anti-Inflammatory Activity of Melissa officinalis L. Essential Oil. Advances in Pharmacological and Pharmaceutical Sciences. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003201