Antiadherent and Antibiofilm Activity of Humulus lupulus L. Derived Products: New Pharmacological Properties
Joint Authors
Rozalski, Marcin
Micota, Bartlomiej
Sadowska, Beata
Stochmal, Anna
Jedrejek, Dariusz
Wieckowska-Szakiel, Marzena
Rozalska, Barbara
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
New antimicrobial properties of products derived from Humulus lupulus L.
such as antiadherent and antibiofilm activities were evaluated.
The growth of gram-positive but not gram-negative bacteria was inhibited to different extents by these compounds.
An extract of hop cones containing 51% xanthohumol was slightly less active against S.
aureus strains (MIC range 31.2–125.0 μg/mL) than pure xanthohumol (MIC range 15.6–62.5 μg/mL).
The spent hop extract, free of xanthohumol, exhibited lower but still relevant activity (MIC range 1-2 mg/mL).
There were positive coactions of hop cone, spent hop extracts, and xanthohumol with oxacillin against MSSA and with linezolid against MSSA and MRSA.
Plant compounds in the culture medium at sub-MIC concentrations decreased the adhesion of Staphylococci to abiotic surfaces, which in turn caused inhibition of biofilm formation.
The rate of mature biofilm eradication by these products was significant.
The spent hop extract at MIC reduced biofilm viability by 42.8%, the hop cone extract by 74.8%, and pure xanthohumol by 86.5%.
When the hop cone extract or xanthohumol concentration was increased, almost complete biofilm eradication was achieved (97–99%).
This study reveals the potent antibiofilm activity of hop-derived compounds for the first time.
American Psychological Association (APA)
Rozalski, Marcin& Micota, Bartlomiej& Sadowska, Beata& Stochmal, Anna& Jedrejek, Dariusz& Wieckowska-Szakiel, Marzena…[et al.]. 2013. Antiadherent and Antibiofilm Activity of Humulus lupulus L. Derived Products: New Pharmacological Properties. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003236
Modern Language Association (MLA)
Rozalski, Marcin…[et al.]. Antiadherent and Antibiofilm Activity of Humulus lupulus L. Derived Products: New Pharmacological Properties. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1003236
American Medical Association (AMA)
Rozalski, Marcin& Micota, Bartlomiej& Sadowska, Beata& Stochmal, Anna& Jedrejek, Dariusz& Wieckowska-Szakiel, Marzena…[et al.]. Antiadherent and Antibiofilm Activity of Humulus lupulus L. Derived Products: New Pharmacological Properties. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003236