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Why Is Diabetes Mellitus a Risk Factor for Contrast-Induced Nephropathy?
Joint Authors
Heyman, Samuel N.
Rosenberger, Christian
Rosen, Seymour
Khamaisi, Mogher
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Contrast-induced nephropathy (CIN) remains a leading cause of iatrogenic acute kidney injury, as the usage of contrast media for imaging and intravascular intervention keeps expanding.
Diabetes is an important predisposing factor for CIN, particularly in patients with renal functional impairment.
Renal hypoxia, combined with the generation of reactive oxygen species, plays a central role in the pathogenesis of CIN, and the diabetic kidney is particularly susceptible to intensified hypoxic and oxidative stress following the administration of contrast media.
The pathophysiology of this vulnerability is complex and involves various mechanisms, including a priori enhanced tubular transport activity, oxygen consumption, and the generation of reactive oxygen species.
The regulation of vascular tone and peritubular blood flow may also be altered, particularly due to defective nitrovasodilation, enhanced endothelin production, and a particular hyperresponsiveness to adenosine-related vasoconstriction.
In addition, micro- and macrovascular diseases and chronic tubulointerstitial changes further compromise regional oxygen delivery, and renal antioxidant capacity might be hampered.
A better understanding of these mechanisms and their control in the diabetic patient may initiate novel strategies in the prevention of contrast nephropathy in these susceptible patients.
American Psychological Association (APA)
Heyman, Samuel N.& Rosenberger, Christian& Rosen, Seymour& Khamaisi, Mogher. 2013. Why Is Diabetes Mellitus a Risk Factor for Contrast-Induced Nephropathy?. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003279
Modern Language Association (MLA)
Heyman, Samuel N.…[et al.]. Why Is Diabetes Mellitus a Risk Factor for Contrast-Induced Nephropathy?. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1003279
American Medical Association (AMA)
Heyman, Samuel N.& Rosenberger, Christian& Rosen, Seymour& Khamaisi, Mogher. Why Is Diabetes Mellitus a Risk Factor for Contrast-Induced Nephropathy?. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003279