Two-Photon Photodynamic Therapy by Water-Soluble Self-Assembled Conjugated Porphyrins
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Studies on two-photon absorption (2PA) photodynamic therapy (PDT) by using three water-soluble porphyrin self-assemblies consisting of ethynylene-linked conjugated bis (imidazolylporphyrin) are reviewed.
2PA cross-section values in water were obtained by an open aperture Z-scan measurement, and values were extremely large compared with those of monomeric porphyrins such as hematoporphyrin.
These compounds were found to generate singlet oxygen efficiently upon one- as well as two-photon absorption as demonstrated by the time-resolved luminescence measurement at the characteristic band of singlet oxygen at 1270 nm and by using its scavenger.
Photocytotoxicities for HeLa cancer cells were examined and found to be as high as those of hematoporphyrin, demonstrating that these compounds are potential candidates for 2PA-photodynamic therapy agents.
American Psychological Association (APA)
Ogawa, Kazuya& Kobuke, Yoshiaki. 2012. Two-Photon Photodynamic Therapy by Water-Soluble Self-Assembled Conjugated Porphyrins. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1003288
Modern Language Association (MLA)
Ogawa, Kazuya& Kobuke, Yoshiaki. Two-Photon Photodynamic Therapy by Water-Soluble Self-Assembled Conjugated Porphyrins. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1003288
American Medical Association (AMA)
Ogawa, Kazuya& Kobuke, Yoshiaki. Two-Photon Photodynamic Therapy by Water-Soluble Self-Assembled Conjugated Porphyrins. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1003288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003288