![](/images/graphics-bg.png)
Effect of Nerium oleander (N.O.) Leaves Extract on Serum hepcidin, Total Iron, and Infiltration of ED1 Positive Cells in Albino Rat
Joint Authors
Abbasi, Muddasir Hassan
Fatima, Sana
Naz, Naila
Malik, Ihtzaz A.
Sheikh, Nadeem
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To gain insight into the hepatohistological alterations in noninjured rat liver, Nerium oleander (N.O.) leaves extract was injected intramuscularly to induce an acute phase reaction (APR).
Histopathological changes were studied after 3, 12, and 24 h time course of sterile muscle abscess.
Tissue integrity and any infiltration of inflammatory cells in the liver were investigated by Hematoxylin and Eosin and ED1 peroxidase stainings.
The administration of N.O.
leaves extract (10 mL/kg) in H & E stained sections showed a general vacuolization of cytoplasm resulting loss of polarity with prominent nucleoli after 3 h of induction.
At 12 h, eccentric nuclei were also observed in the sections.
Marked infiltration of leucocytes with predominate macrophages was also found after 24 h as seen by ED1 positive staining.
In the present study, a possible relationship between serum hepcidin and total iron level was also investigated in vivo.
An early increase of hepcidin and total iron level (3 h) with a maximum at 12 h (P<0.01; P<0.001) was observed.
These changes indicate that sterile muscle abscess may induce APR resulting in hepatic damage which is evident with the recruitment of inflammatory cells into the organ.
American Psychological Association (APA)
Abbasi, Muddasir Hassan& Fatima, Sana& Naz, Naila& Malik, Ihtzaz A.& Sheikh, Nadeem. 2013. Effect of Nerium oleander (N.O.) Leaves Extract on Serum hepcidin, Total Iron, and Infiltration of ED1 Positive Cells in Albino Rat. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003297
Modern Language Association (MLA)
Abbasi, Muddasir Hassan…[et al.]. Effect of Nerium oleander (N.O.) Leaves Extract on Serum hepcidin, Total Iron, and Infiltration of ED1 Positive Cells in Albino Rat. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1003297
American Medical Association (AMA)
Abbasi, Muddasir Hassan& Fatima, Sana& Naz, Naila& Malik, Ihtzaz A.& Sheikh, Nadeem. Effect of Nerium oleander (N.O.) Leaves Extract on Serum hepcidin, Total Iron, and Infiltration of ED1 Positive Cells in Albino Rat. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003297