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Angiopoietin-Like 3 Induces Podocyte F-Actin Rearrangement through Integrin αVβ3FAKPI3K Pathway-Mediated Rac1 Activation
Joint Authors
Lin, Yi
Rao, Jia
Zha, Xi-liang
Xu, Hong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Glomerular podocytes are highly differentiated cells whose foot processes, which are mainly maintained by the architecture of actin filaments, have a unique morphology.
A rearrangement of F-actin in podocytes causes changes in their motility that involve foot process effacement and proteinuria in glomerular diseases.
Members of the Rho family small GTPases, especially RhoA, Rac1, and Cdc42, are key molecules in the regulation of actin cytoskeleton rearrangement.
Our previous study showed that angiopoietin-like 3 (Angptl3) can increase the motility of podocytes in vitro.
In this study, we found that recombinant Angptl3 treatment, together with the activation of Rac1, could cause F-actin rearrangement in podocytes.
We also found that these effects could be blocked by an integrin αVβ3 inhibitor, implicating integrin αVβ3 as the Angptl3 receptor in its effects on actin cytoskeleton rearrangement.
In addition, we studied the molecular pathway for this process.
Our results showed that in podocytes, Angptl3 could induce actin filament rearrangement, mainly in lamellipodia formation, and that this process was mediated by integrin αVβ3-mediated FAK and PI3K phosphorylation and Rac1 activation.
Our results might provide a new explanation for the effect of Angptl3 on increasing podocyte motility.
American Psychological Association (APA)
Lin, Yi& Rao, Jia& Zha, Xi-liang& Xu, Hong. 2013. Angiopoietin-Like 3 Induces Podocyte F-Actin Rearrangement through Integrin αVβ3FAKPI3K Pathway-Mediated Rac1 Activation. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003335
Modern Language Association (MLA)
Lin, Yi…[et al.]. Angiopoietin-Like 3 Induces Podocyte F-Actin Rearrangement through Integrin αVβ3FAKPI3K Pathway-Mediated Rac1 Activation. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1003335
American Medical Association (AMA)
Lin, Yi& Rao, Jia& Zha, Xi-liang& Xu, Hong. Angiopoietin-Like 3 Induces Podocyte F-Actin Rearrangement through Integrin αVβ3FAKPI3K Pathway-Mediated Rac1 Activation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003335