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Plasma HULC as a Promising Novel Biomarker for the Detection of Hepatocellular Carcinoma
Joint Authors
Xie, Hui
Ma, Hongwei
Zhou, Danqiu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is a leading cause of cancer death in many Asian and African countries.
Lack of early diagnosis tools is one of the clinical obstacles for effective treatment of HCC.
Thus, enhanced understanding of the molecular changes associated with HCC is urgently needed to develop novel strategies for the diagnosis and treatment of this dismal disease.
While aberrant expression of long noncoding RNAs (lncRNAs) has been functionally associated with certain cancers, the expression profiles and biological relevance of lncRNAs in HCC remain unclear.
Highly upregulated in liver cancer (HULC) lncRNA has been implicated in the regulation of hepatoma cell proliferation.
In this study, we demonstrate that HULC expression is significantly higher in HCC tumors compared to normal liver tissues.
Among the tumor tissues, higher HULC expression is positively associated with Edmondson histological grades or with hepatitis B (HBV) positive status.
Moreover, HULC lncRNA is detected with higher frequency in the plasma of HCC patients compared to healthy controls.
Higher HULC detection rates are observed in the plasma of patients with higher Edmondson grades or with HBV+ status.
These findings indicate for the first time that the expression of HULC in plasma can be used as a noninvasive promising novel biomarker for the diagnosis and/or prognosis of HCC.
American Psychological Association (APA)
Xie, Hui& Ma, Hongwei& Zhou, Danqiu. 2013. Plasma HULC as a Promising Novel Biomarker for the Detection of Hepatocellular Carcinoma. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1003343
Modern Language Association (MLA)
Xie, Hui…[et al.]. Plasma HULC as a Promising Novel Biomarker for the Detection of Hepatocellular Carcinoma. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1003343
American Medical Association (AMA)
Xie, Hui& Ma, Hongwei& Zhou, Danqiu. Plasma HULC as a Promising Novel Biomarker for the Detection of Hepatocellular Carcinoma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1003343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003343