Impact of Pregnancy on Zonisamide Pharmacokinetics in Rabbits
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pregnancy is associated with various physiological changes which may lead to significant alterations in the pharmacokinetics of many drugs.
The present study was aimed to investigate the potential effects of pregnancy on the pharmacokinetic profile of zonisamide (ZNM) in the rabbit.
Seven female rabbits were used in this study.
The pregnant and nonpregnant rabbits received ZNM orally at a dose of 10 mg/kg and blood samples were collected from the animals just before receiving the drug and then serially for up to 24 h.
The plasma samples were analyzed using tandem mass spectrometric method.
Following a single oral dose of ZNM to the rabbits, the mean values of ZNM plasma concentrations at different times were consistently low in pregnant compared to nonpregnant rabbits.
The mean values of ZNM’s Cmax and AUC0-∞ were significantly (P<0.05) decreased, whereas the CL/F exhibited substantial increase (P<0.05) in pregnant compared to nonpregnant rabbits.
Tmax, t1/2abs, t1/2el, MRT, and Vd/F showed no significant differences between the two groups.
The present study demonstrates that pregnancy decreased ZNM plasma concentrations in rabbits and that the decrease could be due to decreased extent of gastrointestinal absorption, induced hepatic metabolism, or enhanced renal elimination of the drug.
American Psychological Association (APA)
Matar, Kamal M.. 2013. Impact of Pregnancy on Zonisamide Pharmacokinetics in Rabbits. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1003376
Modern Language Association (MLA)
Matar, Kamal M.. Impact of Pregnancy on Zonisamide Pharmacokinetics in Rabbits. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1003376
American Medical Association (AMA)
Matar, Kamal M.. Impact of Pregnancy on Zonisamide Pharmacokinetics in Rabbits. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1003376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003376