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Lithium Chloride Enhances Cathepsin H Expression and BMP-4 Degradation in C3H10T12 Cells
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The effect of canonical Wnt/β-catenin signaling on chondrogenic differentiation induced by transfection of BMP4 expressing plasmid was analyzed.
Lithium chloride (LiCl) which mimics canonical Wnt/β-catenin signaling was added to cells transfected with BMP4 expressing plasmid.
Although BMP4 mRNA expression was not affected by LiCl, LiCl decreased BMP4 protein accumulation.
Gene expression analysis exhibited upregulation of cathepsin H by LiCl treatment.
Gene silencing of cathepsin H enhanced BMP4 protein accumulation from BMP4 expressing cells.
These results suggested that cathepsin H is regulated by Wnt/β-catenin signaling and plays an important role in the regulation of BMP4 biological activity.
American Psychological Association (APA)
Kishimoto, Koshi N.& Itoi, Eiji. 2013. Lithium Chloride Enhances Cathepsin H Expression and BMP-4 Degradation in C3H10T12 Cells. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003402
Modern Language Association (MLA)
Kishimoto, Koshi N.& Itoi, Eiji. Lithium Chloride Enhances Cathepsin H Expression and BMP-4 Degradation in C3H10T12 Cells. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003402
American Medical Association (AMA)
Kishimoto, Koshi N.& Itoi, Eiji. Lithium Chloride Enhances Cathepsin H Expression and BMP-4 Degradation in C3H10T12 Cells. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003402