Inhibition of Carrageenan-Induced Acute Inflammation in Mice by Oral Administration of Anthocyanin Mixture from Wild Mulberry and Cyanidin-3-Glucoside
Joint Authors
Hassimotto, Neuza Mariko Aymoto
Moreira, Vanessa
Nascimento, Neide Galvão do
Souto, Pollyana Cristina Maggio de Castro
Teixeira, Catarina
Lajolo, Franco Maria
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Anthocyanins are flavonoids which demonstrated biological activities in in vivo and in vitro models.
Here in the anti-inflammatory properties of an anthocyanin-enriched fraction (AF) extracted from wild mulberry and the cyanidin-3-glucoside (C3G), the most abundant anthocyanin in diet, were studied in two acute inflammation experimental models, in the peritonitis and in the paw oedema assays, both of which were induced by carrageenan (cg) in mice.
In each trial, AF and C3G (4 mg/100 g/animal) were orally administered in two distinct protocols: 30 min before and 1 h after cg stimulus.
The administration of both AF and C3G suppresses the paw oedema in both administration times (P<0.05).
In the peritonitis, AF and C3G reduced the polymorphonuclear leukocytes (PMN) influx in the peritoneal exudates when administered 1 h after cg injection.
AF was more efficient reducing the PMN when administered 30 min before cg.
Both AF and C3G were found to suppress mRNA as well as protein levels of COX-2 upregulated by cg in both protocols, but the inhibitory effect on PGE2 production in the peritoneal exudates was observed when administered 30 min before cg (P<0.05).
Our findings suggest that AF and C3G minimize acute inflammation and they present positive contributions as dietary supplements.
American Psychological Association (APA)
Hassimotto, Neuza Mariko Aymoto& Moreira, Vanessa& Nascimento, Neide Galvão do& Souto, Pollyana Cristina Maggio de Castro& Teixeira, Catarina& Lajolo, Franco Maria. 2012. Inhibition of Carrageenan-Induced Acute Inflammation in Mice by Oral Administration of Anthocyanin Mixture from Wild Mulberry and Cyanidin-3-Glucoside. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003421
Modern Language Association (MLA)
Hassimotto, Neuza Mariko Aymoto…[et al.]. Inhibition of Carrageenan-Induced Acute Inflammation in Mice by Oral Administration of Anthocyanin Mixture from Wild Mulberry and Cyanidin-3-Glucoside. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1003421
American Medical Association (AMA)
Hassimotto, Neuza Mariko Aymoto& Moreira, Vanessa& Nascimento, Neide Galvão do& Souto, Pollyana Cristina Maggio de Castro& Teixeira, Catarina& Lajolo, Franco Maria. Inhibition of Carrageenan-Induced Acute Inflammation in Mice by Oral Administration of Anthocyanin Mixture from Wild Mulberry and Cyanidin-3-Glucoside. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003421