LRP-1: A Checkpoint for the Extracellular Matrix Proteolysis
Joint Authors
Etique, Nicolas
Verzeaux, Laurie
Dedieu, Stéphane
Emonard, Hervé
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Low-density lipoprotein receptor-related protein-(LRP-1) is a large endocytic receptor that binds more than 35 ligands and exhibits signaling properties.
Proteinases capable of degrading extracellular matrix (ECM), called matrix proteinases in this paper, are mainly serine proteinases: the activators of plasminogen into plasmin, tissue-type (tPA) and urokinase-type (uPA) plasminogen activators, and the members of the matrix metalloproteinase (MMP) family.
LRP-1 is responsible for clearing matrix proteinases, complexed or not with inhibitors.
This paper attempts to summarize some aspects on the cellular and molecular bases of endocytic and signaling functions of LRP-1 that modulate extra- and pericellular levels of matrix proteinases.
American Psychological Association (APA)
Etique, Nicolas& Verzeaux, Laurie& Dedieu, Stéphane& Emonard, Hervé. 2013. LRP-1: A Checkpoint for the Extracellular Matrix Proteolysis. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003456
Modern Language Association (MLA)
Etique, Nicolas…[et al.]. LRP-1: A Checkpoint for the Extracellular Matrix Proteolysis. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1003456
American Medical Association (AMA)
Etique, Nicolas& Verzeaux, Laurie& Dedieu, Stéphane& Emonard, Hervé. LRP-1: A Checkpoint for the Extracellular Matrix Proteolysis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003456