Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin
Joint Authors
Khvostov, Mikhail V.
Chernonosov, Alexander A.
Tolstikova, Tatjana G.
Kasakin, Marat F.
Fedorova, Olga S.
Dushkin, Alexander V.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A pharmacokinetic study of the warfarin (WF) : arabinogalactan (AG) complex with the 1 : 10 mass ratio after its intragastric introduction to Wistar rats at a dose of 5 mg/kg (WF dose in the complex was 0.5 mg/kg) once a day for three days was conducted.
It was found that Cmax, T1/2, and AUC of WF in the complex form were lower than after the introduction of blank WF at the same dose, but its elimination (Cl, MRT) was much faster.
Significant accumulation (Cmin) and an abrupt increase in plasma concentration after the third introduction were observed for blank WF, whereas the complex showed a much more moderate increase in concentration at this point.
However, despite obvious differences in pharmacokinetic parameters, the efficacies of both agents were virtually identical; the complex differed from blank WF by only 15%.
This value is rather insignificant and does not impair its anticoagulant activity.
Thus, we can conclude that introduction of the WF : AG complex is safe in terms of reduction of the bleeding risk and accumulation.
American Psychological Association (APA)
Khvostov, Mikhail V.& Chernonosov, Alexander A.& Tolstikova, Tatjana G.& Kasakin, Marat F.& Fedorova, Olga S.& Dushkin, Alexander V.. 2013. Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin. BioMed Research International،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1003518
Modern Language Association (MLA)
Khvostov, Mikhail V.…[et al.]. Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin. BioMed Research International No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1003518
American Medical Association (AMA)
Khvostov, Mikhail V.& Chernonosov, Alexander A.& Tolstikova, Tatjana G.& Kasakin, Marat F.& Fedorova, Olga S.& Dushkin, Alexander V.. Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1003518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003518