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Psychomotor Retardation in Depression: A Systematic Review of Diagnostic, Pathophysiologic, and Therapeutic Implications
Joint Authors
Bennabi, Djamila
Vandel, Pierre
Papaxanthis, Charalambos
Pozzo, Thierry
Haffen, Emmanuel
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-30
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Psychomotor retardation is a central feature of depression which includes motor and cognitive impairments.
Effective management may be useful to improve the classification of depressive subtypes and treatment selection, as well as prediction of outcome in patients with depression.
The aim of this paper was to review the current status of knowledge regarding psychomotor retardation in depression, in order to clarify its role in the diagnostic management of mood disorders.
Retardation modifies all the actions of the individual, including motility, mental activity, and speech.
Objective assessments can highlight the diagnostic importance of psychomotor retardation, especially in melancholic and bipolar depression.
Psychomotor retardation is also related to depression severity and therapeutic change and could be considered a good criterion for the prediction of therapeutic effect.
The neurobiological process underlying the inhibition of activity includes functional deficits in the prefrontal cortex and abnormalities in dopamine neurotransmission.
Future investigations of psychomotor retardation should help improve the understanding of the pathophysiological mechanisms underlying mood disorders and contribute to improving their therapeutic management.
American Psychological Association (APA)
Bennabi, Djamila& Vandel, Pierre& Papaxanthis, Charalambos& Pozzo, Thierry& Haffen, Emmanuel. 2013. Psychomotor Retardation in Depression: A Systematic Review of Diagnostic, Pathophysiologic, and Therapeutic Implications. BioMed Research International،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1003556
Modern Language Association (MLA)
Bennabi, Djamila…[et al.]. Psychomotor Retardation in Depression: A Systematic Review of Diagnostic, Pathophysiologic, and Therapeutic Implications. BioMed Research International No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-1003556
American Medical Association (AMA)
Bennabi, Djamila& Vandel, Pierre& Papaxanthis, Charalambos& Pozzo, Thierry& Haffen, Emmanuel. Psychomotor Retardation in Depression: A Systematic Review of Diagnostic, Pathophysiologic, and Therapeutic Implications. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1003556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003556