VEGF and bFGF Gene Polymorphisms in Patients with Non-Hodgkin's Lymphoma
Joint Authors
Wróbel, Tomasz
Mazur, Grzegorz
Dzietczenia, Justyna
Gębura, Katarzyna
Kuliczkowski, Kazimierz
Bogunia-Kubik, Katarzyna
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Angiogenesis and lymphangiogenesis are important in the proliferation and survival of the malignant hematopoietic neoplasms, including non-Hodgkin’s lymphomas (NHLs).
Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) play an important role in the initiation of angiogenesis.
Both VEGF and bFGF have been reported to have prognostic significance in NHL.
The present study aimed to determine an association between the VEGF and bFGF gene polymorphisms and disease susceptibility and progression.
VEGF (rs3025039; 936 C>T) and bFGF (rs308395, −921 G>C) variants were determined in 78 NHL patients and 122 healthy individuals by PCR-RFLP technique.
The presence of the VEGF 936T allele was found to significantly associate with worse prognosis of the disease (expressed by the highest International Prognostic Index (IPI)) (0.41 versus 0.20, P=0.044 for IPI 4 among patients having and lacking the T allele).
The VEGF 936T variant was also more frequent among patients with IPI 4 than in controls (OR = 3.37, P=0.029).
The bFGF −921G variant was more frequently detected among patients with aggressive as compared to those with indolent histological subtype (0.37 versus 0.18, P=0.095) and healthy individuals (0.37 versus 0.19, OR = 2.51, P=0.038).
These results imply that VEGF and bFGF gene polymorphisms have prognostic significance in patients with NHL.
American Psychological Association (APA)
Wróbel, Tomasz& Mazur, Grzegorz& Dzietczenia, Justyna& Gębura, Katarzyna& Kuliczkowski, Kazimierz& Bogunia-Kubik, Katarzyna. 2013. VEGF and bFGF Gene Polymorphisms in Patients with Non-Hodgkin's Lymphoma. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003565
Modern Language Association (MLA)
Wróbel, Tomasz…[et al.]. VEGF and bFGF Gene Polymorphisms in Patients with Non-Hodgkin's Lymphoma. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1003565
American Medical Association (AMA)
Wróbel, Tomasz& Mazur, Grzegorz& Dzietczenia, Justyna& Gębura, Katarzyna& Kuliczkowski, Kazimierz& Bogunia-Kubik, Katarzyna. VEGF and bFGF Gene Polymorphisms in Patients with Non-Hodgkin's Lymphoma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003565