Genetic Variation between Biomphalaria alexandrina Snails Susceptible and Resistant to Schistosoma mansoni Infection
Joint Authors
El-Nassery, Suzanne M. F.
Abou-El-Naga, Iman F.
Allam, Sonia R.
Shaat, Eman A.
Mady, Rasha F. M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Much effort has been made to control schistosomiasis infection in Egypt.
However, enduring effects from such strategies have not yet been achieved.
In this study, we sought to determine the genetic variability related to the interaction between Biomphalaria alexandrina snails and Schistosoma mansoni.
Using RAPD-PCR with eight (10 mers) random primers, we were able to determine the polymorphic markers that differed between snails susceptible and resistant to Schistosoma mansoni infection using five primers out of the eight.
Our results suggest that the RAPD-PCR technique is an efficient means by which to compare genomes and to detect genetic variations between schistosomiasis intermediate hosts.
The RAPD technique with the above-noted primers can identify genomic markers that are specifically related to the Biomphalaria alexandrina/Schistosoma mansoni relationship in the absence of specific nucleotide sequence information.
This approach could be used in epidemiologic surveys to investigate genetic diversity among Biomphalaria alexandrina snails.
The ability to determine resistant markers in Biomphalaria alexandrina snails could potentially lead to further studies that use refractory snails as agents to control the spread of schistosomiasis.
American Psychological Association (APA)
El-Nassery, Suzanne M. F.& Abou-El-Naga, Iman F.& Allam, Sonia R.& Shaat, Eman A.& Mady, Rasha F. M.. 2013. Genetic Variation between Biomphalaria alexandrina Snails Susceptible and Resistant to Schistosoma mansoni Infection. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003568
Modern Language Association (MLA)
El-Nassery, Suzanne M. F.…[et al.]. Genetic Variation between Biomphalaria alexandrina Snails Susceptible and Resistant to Schistosoma mansoni Infection. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1003568
American Medical Association (AMA)
El-Nassery, Suzanne M. F.& Abou-El-Naga, Iman F.& Allam, Sonia R.& Shaat, Eman A.& Mady, Rasha F. M.. Genetic Variation between Biomphalaria alexandrina Snails Susceptible and Resistant to Schistosoma mansoni Infection. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003568