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Immune Responses Associated with Resistance to Haemonchosis in Sheep
Joint Authors
Muñoz-Guzmán, Marco Antonio
Alba-Hurtado, Fernando
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This paper examines the known immunological and genetic factors associated with sheep resistance to infection by Haemonchus contortus.
Such resistance is an inheritable genetic trait (h2, 0.22–0.63) associated with certain sheep breeds.
Resistant sheep do not completely reject the disease; they only harbor fewer parasites than susceptible sheep and therefore have a lower fecal egg count.
Protective immune response to haemonchosis is an expression of genetic resistance.
Genes associated with resistance and susceptibility are described.
Genetically resistant sheep have nonspecific mechanisms that block the initial colonization by Haemonchus contortus larvae.
These sheep also have an efficacious Th2 type response (e.g., increases in blood and tissue eosinophils, specific IgE class antibodies, mast cells, IL-5, IL-13, and TNFα) that protects them against the infection; in contrast, susceptible sheep do not efficiently establish this type of immune response.
Finally, the main reported antigens of H.
contortus were reviewed.
American Psychological Association (APA)
Alba-Hurtado, Fernando& Muñoz-Guzmán, Marco Antonio. 2012. Immune Responses Associated with Resistance to Haemonchosis in Sheep. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1003575
Modern Language Association (MLA)
Alba-Hurtado, Fernando& Muñoz-Guzmán, Marco Antonio. Immune Responses Associated with Resistance to Haemonchosis in Sheep. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1003575
American Medical Association (AMA)
Alba-Hurtado, Fernando& Muñoz-Guzmán, Marco Antonio. Immune Responses Associated with Resistance to Haemonchosis in Sheep. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1003575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003575