Analysis of Structures and Epitopes of Surface Antigen Glycoproteins Expressed in Bradyzoites of Toxoplasma gondii
Joint Authors
Cong, Hua
Zhang, Min
Zhang, Qingli
Gong, Jing
Cong, Haizi
Xin, Qing
He, Shenyi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Toxoplasma gondii is a protozoan parasite capable of infecting humans and animals.
Surface antigen glycoproteins, SAG2C, -2D, -2X, and -2Y, are expressed on the surface of bradyzoites.
These antigens have been shown to protect bradyzoites against immune responses during chronic infections.
We studied structures of SAG2C, -2D, -2X, and -2Y proteins using bioinformatics methods.
The protein sequence alignment was performed by T-Coffee method.
Secondary structural and functional domains were predicted using software PSIPRED v3.0 and SMART software, and 3D models of proteins were constructed and compared using the I-TASSER server, VMD, and SWISS-spdbv.
Our results showed that SAG2C, -2D, -2X, and -2Y are highly homologous proteins.
They share the same conserved peptides and HLA-I restricted epitopes.
The similarity in structure and domains indicated putative common functions that might stimulate similar immune response in hosts.
The conserved peptides and HLA-restricted epitopes could provide important insights on vaccine study and the diagnosis of this disease.
American Psychological Association (APA)
Cong, Hua& Zhang, Min& Zhang, Qingli& Gong, Jing& Cong, Haizi& Xin, Qing…[et al.]. 2013. Analysis of Structures and Epitopes of Surface Antigen Glycoproteins Expressed in Bradyzoites of Toxoplasma gondii. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003584
Modern Language Association (MLA)
Cong, Hua…[et al.]. Analysis of Structures and Epitopes of Surface Antigen Glycoproteins Expressed in Bradyzoites of Toxoplasma gondii. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003584
American Medical Association (AMA)
Cong, Hua& Zhang, Min& Zhang, Qingli& Gong, Jing& Cong, Haizi& Xin, Qing…[et al.]. Analysis of Structures and Epitopes of Surface Antigen Glycoproteins Expressed in Bradyzoites of Toxoplasma gondii. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003584