Allicin Attenuates Inflammation and Suppresses HLA-B27 Protein Expression in Ankylosing Spondylitis Mice
Joint Authors
Gu, Xin
Wu, Haishan
Fu, Peiliang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Here we aimed to determine the therapeutic effect of allicin on ankylosing spondylitis (AS) and explore the mechanism(s) of action.
AS mouse model was constructed by transferring the HLA-B2704 gene into Kunming mice and verified by RT-PCR and CT imaging.
Verified AS mice were randomly divided into model group (n=6) and allicin-treated groups (50, 100, and 200 mg/kg, resp., n=6, p.o., for 2 months).
Wild type mice were used as control (n=6).
The levels of AS-related inflammatory factors were measured by ELISA.
mRNA and protein expressions of HLA-B27 were checked by RT-PCR and western blotting.
As the results, the mouse model of AS was successfully established, and high-dose allicin could markedly alleviate spine inflammatory injury possibly via reducing the secretion of the inflammatory factors (IL-6, IL-8, and TNF-α) sharply in AS mice.
Moreover, allicin significantly inhibited HLA-B27 protein translation but failed to suppress HLA-B27 gene transcription in AS mice, indicating a posttranscriptional mechanism of this modulation.
In conclusion, allicin has potential to be used for AS treatment as an anti-inflammatory nutraceutical.
American Psychological Association (APA)
Gu, Xin& Wu, Haishan& Fu, Peiliang. 2013. Allicin Attenuates Inflammation and Suppresses HLA-B27 Protein Expression in Ankylosing Spondylitis Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003606
Modern Language Association (MLA)
Gu, Xin…[et al.]. Allicin Attenuates Inflammation and Suppresses HLA-B27 Protein Expression in Ankylosing Spondylitis Mice. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1003606
American Medical Association (AMA)
Gu, Xin& Wu, Haishan& Fu, Peiliang. Allicin Attenuates Inflammation and Suppresses HLA-B27 Protein Expression in Ankylosing Spondylitis Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003606