Skin Basement Membrane: The Foundation of Epidermal Integrity—BM Functions and Diverse Roles of Bridging Molecules Nidogen and Perlecan
Joint Authors
Breitkreutz, Dirk
Koxholt, Isabell
Thiemann, Kathrin
Nischt, Roswitha
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The epidermis functions in skin as first defense line or barrier against environmental impacts, resting on extracellular matrix (ECM) of the dermis underneath.
Both compartments are connected by the basement membrane (BM), composed of a set of distinct glycoproteins and proteoglycans.
Herein we are reviewing molecular aspects of BM structure, composition, and function regarding not only (i) the dermoepidermal interface but also (ii) the resident microvasculature, primarily focusing on the per se nonscaffold forming components perlecan and nidogen-1 and nidogen-2.
Depletion or functional deficiencies of any BM component are lethal at some stage of development or around birth, though BM defects vary between organs and tissues.
Lethality problems were overcome by developmental stage- and skin-specific gene targeting or by cell grafting and organotypic (3D) cocultures of normal or defective cells, which allows recapitulating BM formation de novo.
Thus, evidence is accumulating that BM assembly and turnover rely on mechanical properties and composition of the adjacent ECM and the dynamics of molecular assembly, including further “minor” local components, nidogens largely functioning as catalysts or molecular adaptors and perlecan as bridging stabilizer.
Collectively, orchestration of BM assembly, remodeling, and the role of individual players herein are determined by the developmental, tissue-specific, or functional context.
American Psychological Association (APA)
Breitkreutz, Dirk& Koxholt, Isabell& Thiemann, Kathrin& Nischt, Roswitha. 2013. Skin Basement Membrane: The Foundation of Epidermal Integrity—BM Functions and Diverse Roles of Bridging Molecules Nidogen and Perlecan. BioMed Research International،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1003625
Modern Language Association (MLA)
Breitkreutz, Dirk…[et al.]. Skin Basement Membrane: The Foundation of Epidermal Integrity—BM Functions and Diverse Roles of Bridging Molecules Nidogen and Perlecan. BioMed Research International No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-1003625
American Medical Association (AMA)
Breitkreutz, Dirk& Koxholt, Isabell& Thiemann, Kathrin& Nischt, Roswitha. Skin Basement Membrane: The Foundation of Epidermal Integrity—BM Functions and Diverse Roles of Bridging Molecules Nidogen and Perlecan. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1003625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003625