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Long-Term Nitric Oxide Exposure Enhances Lung Cancer Cell Migration
Joint Authors
Chanvorachote, Pithi
Sanuphan, Arpasinee
Chunhacha, Preedakorn
Pongrakhananon, Varisa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nitric oxide (NO) found in the vicinity of lung cancer cells may play a role in the regulation of cancer cell behaviors.
To explore the possible effects of NO on cell motility, human lung cancer cells were exposed to nontoxic concentrations of NO for 0–14 days, and the migratory characteristics of the cells were determined.
The present study found that long-term treatment with NO significantly enhanced cell migration in a dose- and time-dependent manner.
Furthermore, we found that the increased migratory action was associated with the increased expression of caveolin-1 (Cav-1), which in turn activated the focal adhesion kinase (FAK) and ATP-dependent tyrosine kinase (Akt) pathways.
Notably, the NO-treated cells exhibited an increased number of filopodia per cell, as well as an increase in the levels of cell division cycle 42 (Cdc42) protein.
Together, these results indicate that extended NO exposure has a novel effect on cell migration through a Cav-1-dependent mechanism, a finding that strengthens our understanding of cancer biology.
American Psychological Association (APA)
Sanuphan, Arpasinee& Chunhacha, Preedakorn& Pongrakhananon, Varisa& Chanvorachote, Pithi. 2013. Long-Term Nitric Oxide Exposure Enhances Lung Cancer Cell Migration. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003652
Modern Language Association (MLA)
Sanuphan, Arpasinee…[et al.]. Long-Term Nitric Oxide Exposure Enhances Lung Cancer Cell Migration. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003652
American Medical Association (AMA)
Sanuphan, Arpasinee& Chunhacha, Preedakorn& Pongrakhananon, Varisa& Chanvorachote, Pithi. Long-Term Nitric Oxide Exposure Enhances Lung Cancer Cell Migration. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003652
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003652