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The Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in Experimental Studies: A Systematic Review
Joint Authors
Chu, Michael J. J.
Hickey, Anthony J. R.
Phillips, Anthony R. J.
Bartlett, Adam S. J. R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The impact of hepatic steatosis on outcome following hepatic ischemia-reperfusion injury (IRI) remains controversial with conflicting clinical results.
A number of experimental studies have been published examining the relationship between hepatic steatosis and IRI.
This systematic review evaluates these experimental studies.
Methods.
An electronic search of the Medline and Embase databases (January 1946 to June 2012) was performed to identify studies that reported relevant outcomes in animal models of hepatic steatosis subjected to IRI.
Results.
A total of 1314 articles were identified, of which 33 met the predefined criteria and were included in the study.
There was large variation in the type of animal model, duration, and type of IRI and reporting of histological findings.
Increased macrovesicular steatosis (>30%) was associated with increased histological damage, liver function derangement, and reduced survival.
Increased duration of warm or cold ischemia had a negative impact on all outcomes measured.
Microvesicular steatosis did not influence outcome.
Conclusions.
Findings from this systemic review support the hypothesis that livers with >30% macrovesicular steatosis are less tolerant of IRI.
Clinically, it is likely that these findings are applicable to patients undergoing hepatic resection, but further studies are required to confirm these data.
American Psychological Association (APA)
Chu, Michael J. J.& Hickey, Anthony J. R.& Phillips, Anthony R. J.& Bartlett, Adam S. J. R.. 2013. The Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in Experimental Studies: A Systematic Review. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1003662
Modern Language Association (MLA)
Chu, Michael J. J.…[et al.]. The Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in Experimental Studies: A Systematic Review. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1003662
American Medical Association (AMA)
Chu, Michael J. J.& Hickey, Anthony J. R.& Phillips, Anthony R. J.& Bartlett, Adam S. J. R.. The Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in Experimental Studies: A Systematic Review. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1003662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003662