Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro
Joint Authors
Zhao, Jie
Zhao, Jia-Xi
Xu, Ya-Jun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of this study was to assess whether nucleotides supplementation in vitro could suppress ethanol-induced developmental toxicity in mouse.
The models of whole embryo culture (WEC) and midbrain (MB) cell micromass culture were used in this study.
In WEC system, exposure to 4.0 mg/mL ethanol for 48 h yielded various developmental malformations of the mice embryos.
Nucleotides supplementation (0.16, 0.80, 4.00, 20.00, and 100.00 mg/L) improved the growth parameters to some extent, and the protective effects peaked at 4.00 mg/L.
In MB cell micromass culture system, exposure to 4.0 mg/mL ethanol for 5 days resulted in suppression of proliferation and differentiation.
Supplementation of nucleotides (0.16, 0.80, 4.00, 20.00, and 100.00 mg/L) showed some protective effects, which peaked at 4.00 mg/L, too.
The present research indicated that nucleotides supplementation might be of some benefit in the prevention of ethanol-induced birth defects; however, appropriate dosage requires attention.
American Psychological Association (APA)
Zhao, Jie& Zhao, Jia-Xi& Xu, Ya-Jun. 2013. Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003695
Modern Language Association (MLA)
Zhao, Jie…[et al.]. Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1003695
American Medical Association (AMA)
Zhao, Jie& Zhao, Jia-Xi& Xu, Ya-Jun. Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003695