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Effects of Nanosilver Exposure on Cholinesterase Activities, CD41, and CDFLIF-Like Expression in ZebraFish (Danio rerio) Larvae
Joint Authors
Myrzakhanova, Marzhan
Gambardella, Chiara
Falugi, Carla
Gatti, Antonietta M.
Tagliafierro, Grazia
Ramoino, Paola
Bianchini, Paolo
Diaspro, Alberto
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Metal nanosolicoparticles are suspected to cause diseases in a number of organisms, including man.
In this paper, we report the effects of nanosilver (Ag, 1–20 nm particles) on the early development of the zebrafish, a well-established vertebrate model.
Embryos at the midgastrula stage were exposed to concentrations ranging from 100 to 0.001 mg/L to verify the effects on different endpoints: lethality, morphology, expression of cholinergic molecules, and development of the immune system.
(1) Relative risk of mortality was exponential in the range between 0.001 and 10 mg/L.
Exposure to 100 mg/L caused 100% death of embryos before reaching the tail-bud stage.
(2) Developmental anomalies were present in the 72 h larvae obtained from embryos exposed to nanosilver: whole body length, decreased eye dimension, and slow response to solicitation by gentle touch with a needle tip, with a significant threshold at 0.1 mg/L.
(3) Dose-dependent inhibition of acetylcholinesterase activity was significant among the exposures, except between 1 mg/L and 10 mg/L.
(4) The distribution of CD41+ cells and of CDF/LIF-like immunoreactivity was altered according to the Ag concentration.
The possible effect of nanosilver in impairing immune system differentiation through the inhibition of molecules related to the cholinergic system is discussed.
American Psychological Association (APA)
Myrzakhanova, Marzhan& Gambardella, Chiara& Falugi, Carla& Gatti, Antonietta M.& Tagliafierro, Grazia& Ramoino, Paola…[et al.]. 2013. Effects of Nanosilver Exposure on Cholinesterase Activities, CD41, and CDFLIF-Like Expression in ZebraFish (Danio rerio) Larvae. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1003698
Modern Language Association (MLA)
Myrzakhanova, Marzhan…[et al.]. Effects of Nanosilver Exposure on Cholinesterase Activities, CD41, and CDFLIF-Like Expression in ZebraFish (Danio rerio) Larvae. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1003698
American Medical Association (AMA)
Myrzakhanova, Marzhan& Gambardella, Chiara& Falugi, Carla& Gatti, Antonietta M.& Tagliafierro, Grazia& Ramoino, Paola…[et al.]. Effects of Nanosilver Exposure on Cholinesterase Activities, CD41, and CDFLIF-Like Expression in ZebraFish (Danio rerio) Larvae. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1003698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003698