Prognostic Value of Combined Aquaporin 3 and Aquaporin 5 Overexpression in Hepatocellular Carcinoma
Joint Authors
Guo, Xiaodong
Sun, Ting
Yang, Mei
Li, Zhiyan
Li, Zhiwei
Gao, Yuejuan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aquaporin (AQP) 3 and AQP 5 are involved in tumorigenesis and tumor progression of several tumor types.
Aim.
To investigate expression patterns and clinical significance of AQP3 and AQP5 in hepatocellular carcinoma (HCC).
Methods.
Immunohistochemistry was performed to detect the expression of AQP3 and AQP5 in HCC tissues.
Results.
Immunohistochemistry analysis showed the increased expression of AQP3 and AQP5 protein levels in HCC tissues compared with their adjacent nonneoplastic tissues (both P<0.001).
In addition, combined AQP3 and AQP5 protein expression was significantly associated with serum AFP (P=0.008), tumor stage (P=0.006), and tumor grade (P=0.006).
Moreover, HCC patients highly expressing both AQP3 and AQP5 proteins had worse 5-year disease-free survival and 5-year overall survival (P=0.002 and 0.005, resp.).
Furthermore, the Cox proportional hazards model showed that combined AQP3 and AQP5 protein expression was an independent poor prognostic factor for both 5-year disease-free survival (P=0.009) and 5-year overall survival (P=0.01) in HCC.
Conclusion.
Our data suggest for the first time that the aberrant expression of AQP3 and AQP5 proteins may be strongly related to tumor progression and prognosis in patients with HCC.
The overexpression of AQP3 in combination with upregulation of AQP5 may be an unfavorable prognostic factor for HCC.
American Psychological Association (APA)
Guo, Xiaodong& Sun, Ting& Yang, Mei& Li, Zhiyan& Li, Zhiwei& Gao, Yuejuan. 2013. Prognostic Value of Combined Aquaporin 3 and Aquaporin 5 Overexpression in Hepatocellular Carcinoma. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003704
Modern Language Association (MLA)
Guo, Xiaodong…[et al.]. Prognostic Value of Combined Aquaporin 3 and Aquaporin 5 Overexpression in Hepatocellular Carcinoma. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1003704
American Medical Association (AMA)
Guo, Xiaodong& Sun, Ting& Yang, Mei& Li, Zhiyan& Li, Zhiwei& Gao, Yuejuan. Prognostic Value of Combined Aquaporin 3 and Aquaporin 5 Overexpression in Hepatocellular Carcinoma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003704