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Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In the present paper, we report the synthesis and pharmacological evaluation of a new series of azo compounds with different groups (1-naphthol, 2-naphthol, and N,N-dimethylaniline) and trifluoromethoxy and fluoro substituents in the scaffold.
All synthesized compounds (5a–5f) showed the most potent mushroom tyrosinase inhibition (IC50 values in the range of 4.39 ± 0.76–1.71 ± 0.49 µM), comparable to the kojic acid, as reference standard inhibitor.
All the novel compounds were characterized by FT-IR, 1H NMR, 13C NMR, and elemental analysis.
American Psychological Association (APA)
Hamidian, Hooshang. 2013. Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003708
Modern Language Association (MLA)
Hamidian, Hooshang. Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1003708
American Medical Association (AMA)
Hamidian, Hooshang. Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003708