Expression of Syndecan-4 and Correlation with Metastatic Potential in Testicular Germ Cell Tumours
Joint Authors
Labropoulou, Vassiliki T.
Skandalis, Spyros S.
Ravazoula, Panagiota
Perimenis, Petros
Karamanos, Nikos K.
Kalofonos, Haralabos P.
Theocharis, Achilleas D.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Although syndecan-4 is implicated in cancer progression, there is no information for its role in testicular germ cell tumours (TGCTs).
Thus, we examined the expression of syndecan-4 in patients with TGCTs and its correlation with the clinicopathological findings.
Immunohistochemical staining in 71 tissue specimens and mRNA analysis revealed significant overexpression of syndecan-4 in TGCTs.
In seminomas, high percentage of tumour cells exhibited membranous and/or cytoplasmic staining for syndecan-4 in all cases.
Stromal staining for syndecan-4 was found in seminomas and it was associated with nodal metastasis (P=0.04), vascular/lymphatic invasion (P=0.01), and disease stage (P=0.04).
Reduced tumour cell associated staining for syndecan-4 was observed in nonseminomatous germ cell tumours (NSGCTs) compared to seminomas.
This loss of syndecan-4 was associated with nodal metastasis (P=0.01), vascular/lymphatic invasion (P=0.01), and disease stage (P=0.01).
Stromal staining for syndecan-4 in NSGCTs did not correlate with any of the clinicopathological variables.
The stromal expression of syndecan-4 in TGCTs was correlated with microvessel density (P=0.03).
Our results indicate that syndecan-4 is differentially expressed in seminomas and NSGCTs and might be a useful marker.
Stromal staining in seminomas and reduced levels of syndecan-4 in tumour cells in NSGCTs are related to metastatic potential, whereas stromal staining in TGCTs is associated with neovascularization.
American Psychological Association (APA)
Labropoulou, Vassiliki T.& Skandalis, Spyros S.& Ravazoula, Panagiota& Perimenis, Petros& Karamanos, Nikos K.& Kalofonos, Haralabos P.…[et al.]. 2013. Expression of Syndecan-4 and Correlation with Metastatic Potential in Testicular Germ Cell Tumours. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003726
Modern Language Association (MLA)
Labropoulou, Vassiliki T.…[et al.]. Expression of Syndecan-4 and Correlation with Metastatic Potential in Testicular Germ Cell Tumours. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1003726
American Medical Association (AMA)
Labropoulou, Vassiliki T.& Skandalis, Spyros S.& Ravazoula, Panagiota& Perimenis, Petros& Karamanos, Nikos K.& Kalofonos, Haralabos P.…[et al.]. Expression of Syndecan-4 and Correlation with Metastatic Potential in Testicular Germ Cell Tumours. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003726