Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations
Joint Authors
Huang, Ping
Yin, Rui-Xing
Huang, Ke-Ke
Zeng, Xiao-Na
Guo, Tao
Lin, Quan-Zhen
Wu, Jian
Wu, Dong-Feng
Li, Hui
Pan, S.-L.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations.
A total of 727 subjects of Mulao and 740 subjects of Han Chinese were included.
Serum low-density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) B levels were higher in Mulao than in Han (P<0.05).
The T allele carriers had higher serum LDL-C and ApoAI levels in Mulao, whereas they had lower high-density lipoprotein cholesterol (HDL-C) levels and ratio of ApoAI to ApoB in Han (P<0.05) than the T allele noncarriers.
Subgroup analyses showed that the T allele carriers had higher HDL-C, LDL-C, and ApoAI levels in Mulao males and lower ApoAI levels and ratio of ApoAI to ApoB in Han males than the T allele noncarriers.
The subjects with TT genotype in Han females also had higher total cholesterol, LDL-C, ApoAI, and ApoB levels than the subjects with CT or CC genotype.
Serum lipid parameters were also correlated with several environmental factors in both ethnic groups.
The differences in the association of KLF14 rs4731702 SNP and serum lipid levels between the two ethnic groups might partly result from different gene-environmental interactions.
American Psychological Association (APA)
Huang, Ping& Yin, Rui-Xing& Huang, Ke-Ke& Zeng, Xiao-Na& Guo, Tao& Lin, Quan-Zhen…[et al.]. 2013. Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1003750
Modern Language Association (MLA)
Huang, Ping…[et al.]. Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1003750
American Medical Association (AMA)
Huang, Ping& Yin, Rui-Xing& Huang, Ke-Ke& Zeng, Xiao-Na& Guo, Tao& Lin, Quan-Zhen…[et al.]. Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1003750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003750