External Mechanical Microstimuli Modulate the Osseointegration of Titanium Implants in Rat Tibiae
Joint Authors
Ammann, Patrick
Zacchetti, Giovanna
Wiskott, Anselm
Cugnoni, Joël
Botsis, J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To assess the effect of external mechanical microstimuli of controlled magnitude on the microarchitecture of the peri-implant bone beds in rat tibiae.
Materials and Methods.
Tibiae of forty rats were fitted with two transcutaneous titanium cylinders.
After healing, the implants were loaded to 1 to 3 N, five days/week for four weeks.
These force levels translated into intraosseous strains of 700±200 με, 1400±400 με, and 2100±600 με.
After sacrifice, the implants’ pullout strength was assessed.
Second, the bone’s microarchitecture was analyzed by microcomputed tomography (μCT) in three discrete regions of interest (ROIs).
Third, the effect of loading on bone material properties was determined by nanoindentation.
Results.
The trabecular BV/TV significantly increased in an ROI of 0.98 mm away from the test implant in the 1 N versus the 3 N group with an opposite trend for cortical thickness.
Pull-out strength significantly increased in the 2 N relatively to the nonstimulated group.
Higher values of E-modulus and hardness were observed in the trabecular bone of the 2 N group.
Conclusion.
The in vivo mechanical loading of implants induces load-dependent modifications in bone microarchitecture and bone material properties in rat tibiae.
In pull-out strength measurements, implant osseointegration was maximized at 2 N (1400±400 με).
American Psychological Association (APA)
Zacchetti, Giovanna& Wiskott, Anselm& Cugnoni, Joël& Botsis, J.& Ammann, Patrick. 2013. External Mechanical Microstimuli Modulate the Osseointegration of Titanium Implants in Rat Tibiae. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003753
Modern Language Association (MLA)
Zacchetti, Giovanna…[et al.]. External Mechanical Microstimuli Modulate the Osseointegration of Titanium Implants in Rat Tibiae. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003753
American Medical Association (AMA)
Zacchetti, Giovanna& Wiskott, Anselm& Cugnoni, Joël& Botsis, J.& Ammann, Patrick. External Mechanical Microstimuli Modulate the Osseointegration of Titanium Implants in Rat Tibiae. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003753