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Circulating microRNAs and Kallikreins before and after Radical Prostatectomy: Are They Really Prostate Cancer Markers?
Joint Authors
Egidi, Maria Giulia
Cochetti, Giovanni
Serva, Maria Rita
Guelfi, Gabriella
Zampini, Danilo
Mechelli, Luca
Mearini, Ettore
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of our study was to monitor serum levels of two miRNAs (miR-21 and miR-141) and three KLKs (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy, in order to characterize their fluctuations after surgery.
38 patients with prostate cancer were included.
miR-21 and miR-141 were quantified through real-time PCR, while ELISA assays were used to quantify hK3 (PSA), hK11, and hK13.
Both miR-21 and miR-141 showed a significant increase at the 5th postoperative day, after which a gradual return to the preoperative levels was recorded.
These findings suggest that miR-21 and miR-141 could be involved in postsurgical inflammatory processes and that radical prostatectomy does not seem to alter their circulating levels.
Postoperative serum kallikreins showed a significant decrease, highlighting the potential usefulness of kallikreins apart from PSA as potential prostate cancer markers.
American Psychological Association (APA)
Egidi, Maria Giulia& Cochetti, Giovanni& Serva, Maria Rita& Guelfi, Gabriella& Zampini, Danilo& Mechelli, Luca…[et al.]. 2013. Circulating microRNAs and Kallikreins before and after Radical Prostatectomy: Are They Really Prostate Cancer Markers?. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1003773
Modern Language Association (MLA)
Egidi, Maria Giulia…[et al.]. Circulating microRNAs and Kallikreins before and after Radical Prostatectomy: Are They Really Prostate Cancer Markers?. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1003773
American Medical Association (AMA)
Egidi, Maria Giulia& Cochetti, Giovanni& Serva, Maria Rita& Guelfi, Gabriella& Zampini, Danilo& Mechelli, Luca…[et al.]. Circulating microRNAs and Kallikreins before and after Radical Prostatectomy: Are They Really Prostate Cancer Markers?. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1003773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003773