![](/images/graphics-bg.png)
Effect of Curcumin on the Increase in Hepatic or Brain Phosphatidylcholine Hydroperoxide Levels in Mice after Consumption of Excessive Alcohol
Joint Authors
Pyun, Chang Won
Han, Kyu-Ho
Hong, Go Eun
Lee, Chi Ho
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Curcumin is a bright yellow compound found in Curcuma longa L., a member of the family Zingiberaceae.
In the present study, we determined whether curcumin protects against oxidative stress in liver and brain in mice fed excessive alcohol.
BALB/c mice were administered 20% alcohol (16 g/kg body weight) with or without curcumin (0.016% in diet) for 12 weeks.
The concentrations of phosphatidylcholine hydroperoxide (PC-OOH) in liver and brain samples were determined using chemiluminescence high-performance liquid chromatography.
Mice treated with ethanol and curcumin significantly (P<0.05) showed a lower hepatic PC-OOH level compared to mice treated with only ethanol.
However, there was no significant difference in the brain PC-OOH level among all mice.
Our finding indicates that the dosage of alcohol might increase the lipid peroxide level of liver but not of brain, and daily curcumin consumption might be protective for liver against alcohol-related oxidative stress in mice.
American Psychological Association (APA)
Pyun, Chang Won& Han, Kyu-Ho& Hong, Go Eun& Lee, Chi Ho. 2013. Effect of Curcumin on the Increase in Hepatic or Brain Phosphatidylcholine Hydroperoxide Levels in Mice after Consumption of Excessive Alcohol. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003774
Modern Language Association (MLA)
Pyun, Chang Won…[et al.]. Effect of Curcumin on the Increase in Hepatic or Brain Phosphatidylcholine Hydroperoxide Levels in Mice after Consumption of Excessive Alcohol. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1003774
American Medical Association (AMA)
Pyun, Chang Won& Han, Kyu-Ho& Hong, Go Eun& Lee, Chi Ho. Effect of Curcumin on the Increase in Hepatic or Brain Phosphatidylcholine Hydroperoxide Levels in Mice after Consumption of Excessive Alcohol. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003774