Postexit Surface Engineering of RetroviralLentiviral Vectors
Joint Authors
Metzner, Christoph
Kochan, Feliks
Dangerfield, John A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gene delivery vectors based on retroviral or lentiviral particles are considered powerful tools for biomedicine and biotechnology applications.
Such vectors require modification at the genomic level in the form of rearrangements to allow introduction of desired genes and regulatory elements (genotypic modification) as well as engineering of the physical virus particle (phenotypic modification) in order to mediate efficient and safe delivery of the genetic information to the target cell nucleus.
Phenotypic modifications are typically introduced at the genomic level through genetic manipulation of the virus producing cells.
However, this paper focuses on methods which allow modification of viral particle surfaces after they have exited the cell, that is, directly on the viral particles in suspension.
These methods fall into three categories: (i) direct covalent chemical modification, (ii) membrane-topic reagents, and (iii) adaptor systems.
Current applications of such techniques will be introduced and their advantages and disadvantages will be discussed.
American Psychological Association (APA)
Metzner, Christoph& Kochan, Feliks& Dangerfield, John A.. 2013. Postexit Surface Engineering of RetroviralLentiviral Vectors. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003806
Modern Language Association (MLA)
Metzner, Christoph…[et al.]. Postexit Surface Engineering of RetroviralLentiviral Vectors. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1003806
American Medical Association (AMA)
Metzner, Christoph& Kochan, Feliks& Dangerfield, John A.. Postexit Surface Engineering of RetroviralLentiviral Vectors. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003806