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Hyperthermia as Adjunct to Intravesical Chemotherapy for Bladder Cancer
Joint Authors
Owusu, Richmond A.
Abern, Michael R.
Inman, Brant A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nonmuscle invasive bladder cancer remains a very costly cancer to manage because of high recurrence rates requiring long-term surveillance and treatment.
Emerging evidence suggests that adjunct and concurrent use of hyperthermia with intravesical chemotherapy after transurethral resection of bladder tumor further reduces recurrence risk and progression to advanced disease.
Hyperthermia has both direct and immune-mediated cytotoxic effect on tumor cells including tumor growth arrest and activation of antitumor immune system cells and pathways.
Concurrent heat application also acts as a sensitizer to intravesical chemotherapy agents.
As such the ability to deliver hyperthermia to the focus of tumor while minimizing damage to surrounding benign tissue is of utmost importance to optimize the benefit of hyperthermia treatment.
Existing chemohyperthermia devices that allow for more localized heat delivery continue to pave the way in this effort.
Current investigational methods involving heat-activated drug delivery selectively to tumor cells using temperature-sensitive liposomes also offer promising ways to improve chemohyperthermia efficacy in bladder cancer while minimizing toxicity to benign tissue.
This will hopefully allow more widespread use of chemohyperthermia to all bladder cancer patients, including metastatic bladder cancer.
American Psychological Association (APA)
Owusu, Richmond A.& Abern, Michael R.& Inman, Brant A.. 2013. Hyperthermia as Adjunct to Intravesical Chemotherapy for Bladder Cancer. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003819
Modern Language Association (MLA)
Owusu, Richmond A.…[et al.]. Hyperthermia as Adjunct to Intravesical Chemotherapy for Bladder Cancer. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1003819
American Medical Association (AMA)
Owusu, Richmond A.& Abern, Michael R.& Inman, Brant A.. Hyperthermia as Adjunct to Intravesical Chemotherapy for Bladder Cancer. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003819