A Novel Framework for the Identification and Analysis of Duplicons between Human and Chimpanzee
Joint Authors
Chuang, Trees-Juen
Wu, Shian-Zu
Huang, Yao-Ting
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Human and other primate genomes consist of many segmental duplications (SDs) due to fixation of copy number variations (CNVs).
Structure of these duplications within the human genome has been shown to be a complex mosaic composed of juxtaposed subunits (called duplicons).
These duplicons are difficult to be uncovered from the mosaic repeat structure.
In addition, the distribution and evolution of duplicons among primates are still poorly investigated.
In this paper, we develop a statistical framework for discovering duplicons via integration of a Hidden Markov Model (HMM) and a permutation test.
Our comparative analysis indicates that the mosaic structure of duplicons is common in CNV/SD regions of both human and chimpanzee genomes, and a subset of core duplicons is shared by the majority of CNVs/SDs.
Phylogenetic analyses using duplicons suggested that most CNVs/SDs share common duplication ancestry.
Many human/chimpanzee duplicons flank both ends of CNVs, which may be hotspots of nonallelic homologous recombination.
American Psychological Association (APA)
Chuang, Trees-Juen& Wu, Shian-Zu& Huang, Yao-Ting. 2013. A Novel Framework for the Identification and Analysis of Duplicons between Human and Chimpanzee. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1003829
Modern Language Association (MLA)
Chuang, Trees-Juen…[et al.]. A Novel Framework for the Identification and Analysis of Duplicons between Human and Chimpanzee. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1003829
American Medical Association (AMA)
Chuang, Trees-Juen& Wu, Shian-Zu& Huang, Yao-Ting. A Novel Framework for the Identification and Analysis of Duplicons between Human and Chimpanzee. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1003829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003829