![](/images/graphics-bg.png)
Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects
Joint Authors
Chang, Chien-Wei
Yeh, Yao-Tsung
Wei, Ren-Jie
Wang, Shen-Nien
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Primary liver cancer is the fifth most common cancer worldwide and the third most common cause of cancer mortality.
Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers.
Major risk factors for HCC include infection with HBV or HCV, alcoholic liver disease, and most probably nonalcoholic fatty liver disease.
In general, men are two to four times more often associated with HCC than women.
It can be suggested that sex hormones including progesterone may play some roles in HCC.
Rather, very limited information discusses its potential involvement in HCC.
This paper thus collects some recent studies of the potential involvement of progesterone and related compounds in HCC from basic and clinical aspects.
In addition, two synthetic progestins, megestrol acetate (MA) and medroxyprogesterone acetate (MPA), will be discussed thoroughly.
It is noted that progesterone can also serve as the precursor for androgens and estrogens produced by the gonadal and adrenal cortical tissues, while men have a higher incidence of HCC than women might be due to the stimulatory effects of androgen and the protective effects of estrogen.
Eventually, this paper suggests a new insight on the associations of progesterone and related compounds with HCC development and treatment.
American Psychological Association (APA)
Yeh, Yao-Tsung& Chang, Chien-Wei& Wei, Ren-Jie& Wang, Shen-Nien. 2013. Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003911
Modern Language Association (MLA)
Yeh, Yao-Tsung…[et al.]. Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003911
American Medical Association (AMA)
Yeh, Yao-Tsung& Chang, Chien-Wei& Wei, Ren-Jie& Wang, Shen-Nien. Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003911