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Mineral and Matrix Changes in Brtl+ Teeth Provide Insights into Mineralization Mechanisms
Joint Authors
Boskey, Adele L.
Verdelis, Kostas
Spevak, Lyudmila
Lukashova, Lyudmila
Beniash, Elia
Yang, Xu
Cabral, Wayne A.
Marini, Joan C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The Brtl/+ mouse is a knock-in model for osteogenesis imperfecta type IV in which a Gly349Cys substitution was introduced into one COL1A1 allele.
To gain insight into the changes in dentin structure and mineral composition in these transgenic mice, the objective of this study was to use microcomputed tomography (micro-CT), scanning electron microscopy (SEM), and Fourier transform infrared imaging (FTIRI) to analyze these structures at 2 and 6 months of age.
Results, consistent with the dental phenotype in humans with type IV OI, showed decreased molar volume and reduced mineralized tissue volume in the teeth without changes in enamel properties.
Increased acid phosphate content was noted at 2 and 6 months by FTIRI, and a trend towards altered collagen structure was noted at 2 but not 6 months in the Brtl/+ teeth.
The increase in acid phosphate content suggests a delay in the mineralization process, most likely associated with the defect in the collagen structure.
It appears that in the Brtl/+ teeth slow maturation of the mineralized structures allows correction of altered mineral content and acid phosphate distribution.
American Psychological Association (APA)
Boskey, Adele L.& Verdelis, Kostas& Spevak, Lyudmila& Lukashova, Lyudmila& Beniash, Elia& Yang, Xu…[et al.]. 2013. Mineral and Matrix Changes in Brtl+ Teeth Provide Insights into Mineralization Mechanisms. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003933
Modern Language Association (MLA)
Boskey, Adele L.…[et al.]. Mineral and Matrix Changes in Brtl+ Teeth Provide Insights into Mineralization Mechanisms. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003933
American Medical Association (AMA)
Boskey, Adele L.& Verdelis, Kostas& Spevak, Lyudmila& Lukashova, Lyudmila& Beniash, Elia& Yang, Xu…[et al.]. Mineral and Matrix Changes in Brtl+ Teeth Provide Insights into Mineralization Mechanisms. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003933