Acute and Chronic Oral Toxicity of a Partially Purified Plaunotol Extract from Croton stellatopilosus Ohba
Joint Authors
Chaotham, Chatchai
Chivapat, Songpol
Chaikitwattana, Anan
De-Eknamkul, Wanchai
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Plaunotol, an acyclic diterpenoid with highly effective antigastric ulcer properties, has been commercially isolated from leaves of Croton stellatopilosus Ohba.
This Thai medicinal plant was traditionally used in the form of crude extracts, suggesting that it is possible to administer these plaunotol-containing extracts without toxicity.
To confirm its safety, the oral toxicity of a partially purified plaunotol extract (PPE) was evaluated in vivo.
The PPE was simply prepared by 95% ethanol reflux extraction followed by hexane partition.
The obtained extract was analyzed and found to contain 43% w/w of plaunotol and another compound, likely a fatty acid-plaunotol conjugate that is considered a major impurity.
Oral administration of PPE to ICR mice and Wistar rats was conducted to evaluate acute and chronic toxicity of the plaunotol extract, respectively.
The acute toxicity study demonstrated that PPE was practically nontoxic based on its high median lethal dose value (LD50=10.25 g/kg).
The chronic toxicity studies also showed the absence of mortality and clinical symptoms in all rats treated with 11–1,100 mg/kg/day of PPE during a 6-month period.
Histopathological and hematological analyses revealed that altered liver and kidney function and increased blood platelet number, but only at the high doses (550–1,100 mg/kg/day).
These results suggest that PPE is potentially safe for further development as a therapeutic agent in humans.
American Psychological Association (APA)
Chaotham, Chatchai& Chivapat, Songpol& Chaikitwattana, Anan& De-Eknamkul, Wanchai. 2013. Acute and Chronic Oral Toxicity of a Partially Purified Plaunotol Extract from Croton stellatopilosus Ohba. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1003948
Modern Language Association (MLA)
Chaotham, Chatchai…[et al.]. Acute and Chronic Oral Toxicity of a Partially Purified Plaunotol Extract from Croton stellatopilosus Ohba. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1003948
American Medical Association (AMA)
Chaotham, Chatchai& Chivapat, Songpol& Chaikitwattana, Anan& De-Eknamkul, Wanchai. Acute and Chronic Oral Toxicity of a Partially Purified Plaunotol Extract from Croton stellatopilosus Ohba. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1003948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003948