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A Machine-Learned Predictor of Colonic Polyps Based on Urinary Metabolomics
Joint Authors
Eisner, Roman
Greiner, Russell
Tso, Victor
Wang, Haili
Fedorak, Richard N.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We report an automated diagnostic test that uses the NMR spectrum of a single spot urine sample to accurately distinguish patients who require a colonoscopy from those who do not.
Moreover, our approach can be adjusted to tradeoff between sensitivity and specificity.
We developed our system using a group of 988 patients (633 normal and 355 who required colonoscopy) who were all at average or above-average risk for developing colorectal cancer.
We obtained a metabolic profile of each subject, based on the urine samples collected from these subjects, analyzed via 1H-NMR and quantified using targeted profiling.
Each subject then underwent a colonoscopy, the gold standard to determine whether he/she actually had an adenomatous polyp, a precursor to colorectal cancer.
The metabolic profiles, colonoscopy outcomes, and medical histories were then analysed using machine learning to create a classifier that could predict whether a future patient requires a colonoscopy.
Our empirical studies show that this classifier has a sensitivity of 64% and a specificity of 65% and, unlike the current fecal tests, allows the administrators of the test to adjust the tradeoff between the two.
American Psychological Association (APA)
Eisner, Roman& Greiner, Russell& Tso, Victor& Wang, Haili& Fedorak, Richard N.. 2013. A Machine-Learned Predictor of Colonic Polyps Based on Urinary Metabolomics. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1003950
Modern Language Association (MLA)
Eisner, Roman…[et al.]. A Machine-Learned Predictor of Colonic Polyps Based on Urinary Metabolomics. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1003950
American Medical Association (AMA)
Eisner, Roman& Greiner, Russell& Tso, Victor& Wang, Haili& Fedorak, Richard N.. A Machine-Learned Predictor of Colonic Polyps Based on Urinary Metabolomics. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1003950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003950